On July 2, a giant alien mothership enters orbit around Earth and deploys several dozen saucer-shaped 'destroyer' spacecraft that quickly lay waste to major cities around the planet. On July 3, the United States conducts a coordinated counterattack that fails. On July 4, a plan is devised to gain access to the interior of the alien mothership in space, in order to plant a nuclear missile.
Cocky researcher Sebastian Caine is working on a project to make living creatures invisible. Determined to achieve the ultimate breakthrough, Caine pushes his team to move to the next phase — using himself as the subject. The test is a success, but when the process can't be reversed and Caine seems doomed to future without flesh, he starts to turn increasingly dangerous.